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6/8/2023 0 Comments Dfind old genome assemblies![]() ![]() melanogaster, the X chromosome adopts a dedicated 3D architecture, where X-linked recruitment sites for the MSL complex, termed high-affinity 2016 Samata and Akhtar 2018), and this appears to be conserved in other drosophilids ( Russo et al. melanogaster, the Male-specific lethal (MSL) complex mediates approximately twofold up-regulation of X-linked genes in males ( Kuroda et al. Which balances the transcriptional output from sex chromosomes between males and females. One example of such a chromosome-wide process is dosage compensation, Regulation at genome-wide or chromosome-wide scales. The observation of genomic rearrangements throughout evolution can raise the question of how they impact mechanisms of transcriptional Apart from being cost-effective, such assemblies at the same time provide additional information about genome conformation. 2013 Kaplan and Dekker 2013 Korbel and Lee 2013 Marie-Nelly et al. Prime examples of such Hi-C-assisted genome assemblies are the mosquitoĪedes aegypti, the domestic goat Capra hircus, or the barley Hordeum vulgare L. Hi-C-derived informationĬan aid for such questions, because contacts between pairs of loci in the whole genome provide linking information to orderĪnd orient genome scaffolds into entire chromosomes. Rearrangements and their impact on 3D genome architecture requires chromosome-length genome assemblies. 2007 Wiegmann and Richards 2018) are typically composed of thousands of scaffolds, which hinder comparisons related to genome organization. melanogaster, current Drosophila genome assemblies ( Drosophila 12 Genomes Consortium et al. It remains unclear whether genome architecture is maintained in highly rearranged, yet related, genomes within a givenĮxcept for D. 2012) whose genome is more than 10-times smaller, more gene-dense, and exposed to faster rates of molecular evolution compared TADs have also been described in non-mammalian species (e.g., Drosophila) ( Sexton et al. Mammals revealed few selected examples in which contiguous orthologous genes inserted at different genomic positions in aĭifferent species maintain TAD integrity ( Vietri Rudan et al. TADs and their boundaries tend to correlate with genomic rearrangements during evolution as interspecies comparisons in Within them referred to as topologically associating domains (TADs) ( Dixon et al. Those techniques revealed several regulatory layers of genome organization, including regions that show preferential contacts Processes such as dosage compensation of the X chromosome.Ĭhromosome conformation capture techniques such as Hi-C provide genome-wide contact maps between loci within chromosomes ( Lieberman-Aiden et al. Therefore, 3D architecture is preserved even in scenarios of thousands of rearrangements highlighting its relevance for essential Evolutionary conserved genes cluster in the vicinity of HAS, while HAS locations appear evolutionarilyįlexible, thus uncoupling functional requirement of dosage compensation from individual positions on the linear X chromosome. High-affinity sites (HAS) located on the X chromosome are maintained over 40 million years, indicating architectural conservationĪt various hierarchies. A/B compartments, a set of large gene-dense topologically associating domains (TADs), and spatial contacts between We observe extensive genome shuffling between these species with one synteny breakpoint after approximately every ![]() Here, we developed a scaffolding algorithm and generated chromosome-length assemblies from Hi-C dataįor studying genome topology in three distantly related Drosophila species. Genome rearrangements that occur during evolution impose major challenges on regulatory mechanisms that rely on three-dimensional ![]() 6/8/2023 0 Comments Pgadmin 4 tutorial![]() ![]() I hope this article is helpful for you, if you like this article, please share and keep visiting for further PostgreSQL tutorials. Now you are able to work with pgAdmin 4 application.pgAdmin 4 is one of the best tools for database administrators who specially work with PostgreSQL database servers because it provides approx all the features within a single application. So, in this guide, we have seen all about how to install pgAdmin 4 in windows machine with the help of proper screenshots. Now pgAdmin will take a little bit of time to install, After installation completed click on Finish button.Click Next.If you don’t want to create program’s shortcut other you can choose folder.Here you can choose the destination location where you want to install pgAdmin 4 other you can avoid it and then click on the Next button.Choose I accept the agreement and click on the next button.Click on the downloaded pgAdmin 4 executable file and choose to install for all the users.Click on pgAdmin exe link to download pgAdmin 4 execute application.During writing this article latest version is pgAdmin 4 v6.4 If you are interested in learning more about the project, or if a pgAdmin installer is not available for your environment, the pages listed below will provide detailed information. Click on the latest version of pgAdmin 4. Pre-compiled and configured installation packages for pgAdmin 4 are available for a number of desktop environments we recommend using an installer whenever possible.In Default user password tab, write a password. 2) While creating the instance, In Instance ID tab, write a name for your instance. Click here to visit pgAdmin 4 windows download page. If you are configuring access for public IP connections, follow the next steps to connect with PgAdmin: 1) Create your PostgreSQL instance in Google Cloud Platform.If you have already downloaded then you can go with the second part. We will break this process into two parts first is downloading pgAdmin 4 latest version and the second is the installation of pgAdmin 4. Backup, restore, vacuum, and analyze on-demand.Īpart from these features, there are also multiple features available inside the pgAdmin tool, which you can check out here.Schema diff tool for demonstrating between schemas.ERD ( Entity-Relationship Diagram ) tool for designing and documenting schemas. ![]() Fast Datagrid for display/entry of data.Powerful query tool with color syntax highlighting.Designed for multiple PostgreSQL versions and derivatives.pgAdmin 4 is available for all windows, macOS, and Linux.Getting Started with PostgreSQL This section helps you get started with PostgreSQL by showing you how to install PostgreSQL on Windows, Linux, and macOS. PgAdmin comes with lots of features that made it popular and attractive. PostgreSQL tutorial demonstrates many unique features of PostgreSQL that make it the most advanced open-source database management system. We can perform all the activities using the pgAdmin application which we are performing on psql shell. This course is perfect for anyone just starting out, you don't need any special skills or prior knowledge to take this course.Īnd as always, we offer a 100% money back guarantee if you aren't completely happy with the course.PgAdmin 4 is one of the most popular open-source administration and development platforms for PostgreSQL.pgAdmin 4 provides a user-friendly user interface where we can manage our PostgreSQL database. Postgres is pretty easy to use! You'll be amazed at how quick and easy it is to dive in and get started! But Postgresql is constantly ranked a top database for everything from data analytics to basic web development - and everything in between. You have many databases to choose from, and even many free databases to choose from. There's a reason why Postgres is so popular, find out why in this course! In this course I'll teach you how to setup and use PostgreSQL databases with the PgAdmin 4 interface! ![]() 6/5/2023 0 Comments Dear esther playthrough![]() These external addons won’t help Dear Esther’s score in this section though.Īlthough the technology is outdated, the presentation and artistic design really help the game’s visuals. The supersampling helps in areas with dense vegetation, and the ambient occlusion just adds a lot to the visuals. So my images look better than the game normally does. Note that these images are taken with 2×2 Supersampling and 4x MSAA enhancements, as well as 4x SGSSAA transparency and most of all, ambient occlusion forced on via NVIDIA Inspector. Shadows are hardly cast by anything, there are lots of low polygon objects, vegetation is 2D and rotates when you revolve around it, and textures are a mixed bag. However, overall it still looks quite a bit outdated. It is very easy to run especially on lower settings, for those of you without a powerful gaming computer. AUDIO & VISUALSĭear Esther is made on the Source engine, and is by far the best looking game on that engine I’ve ever seen. Dear Esther is a unique game that does feel more like a mod for another game (as it originally was), but it is worth a playthrough if you want an interesting story and want to see how much of it you can grasp. There are multiple paths for you to take and you can look around in rather open spaces. It is rather linear, although not like a corridor game. So what’s left to say after this closer look of Dear Esther? It’s a story driven first person adventure game, less than two hours long in my case, advanced language, no action, and a fairly immersive atmosphere. There is no running, crouching, puzzles, enemy encounters or any of that. ![]() Don’t expect an action packed game as the only gameplay element is WASD – walking. I suppose if you’re in need of a game that will mess with your mind, then this is worth the buy. It’s true, those didn’t come out for $10. Keep in mind that this is a $10 game, but there are games with more symbols and messages to the storyline plus lots of gameplay elements (looks at Silent Hill). I found the ending of it to be quite predictable. The story is rather dark and completely personal to the protagonist. Therefore, after playing this game once, it might be worth going back through in the future. The monologues play at specific points on the island and they do so with reason, however the monologue and the points at which they are spoken varies throughout each playthrough. You’ll find caverns, including one specifically large one that is very impressive. Immersion is one of the game’s main attempts, and it does the job. What accident, you might ask? I will leave it up to the player to decipher the symbols and messages found throughout the game, and formulate their own questions and answers. The island is your retreat from the “mainland”, where you pursue your only goal after a terrible accident. In its simplest form, the story of Dear Esthur can be seen as quite simple. These symbols will show up physically throughout the game as well. Pay attention to each bit of monologue – you’ll see many recurring themes, ideas, and symbols. ![]() The game took me just under two hours to complete and it is almost necessary to play it in one setting. Have an imagination when playing this game and you might find it immersive. Is the island real? What is this incident he is describing? What happened to Esther and why is this protagonist alone on an island?Īnswers are there… not for every question mind you. It’s a grown-up game that will let the player make up their own interpretations in the story, something found in only few games such as Cryostasis, Penumbra, Amnesia, and Silent Hill. The language of this game is unlike most. The language of the game is unlike most, and I wouldn’t be surprised if most people fail to comprehend many parts of the story without reading a synopsis or this review.Īs you dwell deeper into the mysterious island, the monologues get more complex and conflicting. This game puts you in complete isolation as you advance through this mysterious island with monologue full of symbolism, imagery, personification, metaphors, and other literary elements. As you progress through the game, there will be no battles, puzzles, or interaction with other creatures. So what is this game about? Dear Esther puts you in the shoes of a lonely man on an island. ![]() 6/5/2023 0 Comments Soundwaves nashville![]() ![]() Dine at any of Gaylord Opryland Resort’s unique restaurants, including The Falls Bar & Lounge where you can enjoy atrium and indoor waterfall views or Old Hickory Steakhouse for an elegant night out. Explore the stunning garden atriums, complete with a quarter-mile-long indoor river! The resort hosts many seasonal, family-friendly events and activities like a scavenger hunt, live shows, escape rooms, pirate and princess-themed adventures and more. Just down the road from the Grand Ole Opry is the largest resort in the state - Gaylord Opryland Resort & Convention Center. ![]() Enhance your experience with the backstage tour to see treasured mementos, photographs and videos of iconic moments in country music. With lineups that include shows by the greats, music from rising stars and even family-friendly comedy, you never know who will take the stage next. The indoor/outdoor facility features a variety of water rides, including a total of 11. As the show grew, it moved to the Ryman Auditorium and then to its current location, the Opry House. The Gaylord Opryland Resort & Convention Center stresses that its SoundWaves is an 'upscale' water park. The Grand Ole Opry has been home to country music for nearly a century, since its first radio show aired in 1925. Learn about the musicians who have shaped this rich, American genre like Hank Williams, one of the original inductees in 1961, and his son Hank Williams Jr., who joined the exclusive ranks last year.Īfter learning about some of country music’s most notable singers and songwriters, see them perform live at the Grand Ole Opry, the most famous venue in Nashville. It’s called Music City for a reason, and no trip would be complete without a stop at the Country Music Hall of Fame and Museum. Make this year’s staycation one for the books in beautiful Nashville, Tennessee. As summer begins, we’ve compiled the top seven can’t-miss stops, from country music landmarks to unique aquatic experiences. ![]() For locals, it can be easy to forget the incredible attractions and opportunities for family-friendly fun. With a rich music history, beautiful outdoor settings and unparalleled entertainment options, it’s no mystery why tourists flock to the city. Attracting visitors from all over the world, Nashville is a place like no other. ![]() 6/5/2023 0 Comments Snapgene prices per base![]() ![]() Sticky ends from different BaeGI sites may not be compatible. Sticky ends from different StyI sites may not be compatible. ![]() Sticky ends from different BtgI sites may not be compatible. Prolonged incubation with NdeI may lead to removal of additional nucleotides. 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Blackbeard would later reemerge in Pirates of the Caribbean, but as a forgettable villain who recruits crew in a novel way – his daughter Angelica pretends as Jack Sparrow. Within the first few minutes of the third film, the song effectively discloses Jones’ past to the audience, demonstrating how much effort went into Gore Verbinski’s trilogy’s narrative. The line “ The king and his men/Stole the queen from her bed/And bound her in her bones” clearly refers to the first Brethren Court, reminding listeners of the Pirate Lords’ perceived power while also teasing the truth about Jones’ assistance, which ultimately leads to Davy Jones’ octopus-like appearance. This aspect may go undetected at first, especially with so many storey threads to follow, but the song does truly reflect the pirates’ independence after confining Calypso in human form. “ Every one of the verses tells the storey of Davy Jones and Calypso,” Elliot says. The song’s lyrics, however, reveal the origin of the Flying Dutchman’s captain, which the heroes of Pirates of the Caribbean were first unaware of. Before the film’s finale, while the pirate army prepares for a fight. The song is dangerous since it is a rallying cry for fellow pirates, which is exactly what the crew of the Black Pearl wants. He is first mentioned in The Curse of the Black Pearl, appears as one of the main antagonists in Dead Mans Chest and At Worlds End, and makes a cameo appearance in Dead Men Tell No Tales. The writers were dismayed to realise that this was merely a legend. Davy Jones is a fictional character in the Pirates of the Caribbean film series, portrayed by Bill Nighy. Sixpence was allegedly the daily salary sailors received, while “Four and twenty blackbirds/Baked in a pie” represented his strategy of surprise attacks, which involved pretending a need for assistance in order to lure passing vessels into a trap. ![]() ![]() Each song held a hidden message about serving Blackbeard, which was hinted at in the first film. However, after turning up unsuccessful in tracing the term’s origin, historians argue that its root went back centuries ago, and the stories were shared with generations by word of mouth.As a key inspiration, Ted Elliot mentions a lengthy examination (via Snopes) at the myth behind “ Sing a Song of Sixpence.” When Blackbeard arrived in a port, his men sang this song to inform locals that he was hunting for a crew, according to folklore. In the early days, the name Davy Jones was referred to as the sailors’ devil and, sometimes, the evil god of the seas. Still, in its figurative sense, the phrase has been part of the English language for a long while, and the origin of the word remains disputed. Sailors use the phrase to suggest an afterlife for seafarers or even objects, including ships fated to rest at the ocean’s bottom in a graveyard. However, the real story behind the phrase is quite different from its fictionalized versions, but some legend details seem to be true.Īccording to the mythology of sailors, the phrase “Davy Jones’s Locker” is an expression that refers to the seabed, the final resting place of the thousands of sailors who have drowned at sea. Obviously we are talking about the dreaded Davy JonesTh. In the movie, the locker is a desolate coastline, but over the centuries, the locker has taken on several myths and depictions. Welcome to this video on Disneys best idealized villain, in Pirates of the Caribbeans universe. When most think of Davy Jones, they think of Davy Jones’ Locker, where the pirate sent Jack Sparrow and his ship, the Black Pearl, to pay Jack’s debt. He was a cruel captain who sailed the seas collecting souls and damned them to serve on his ship for eternity. Davy Jones is portrayed in “Pirates of the Caribbean” as an octopus-faced man with tentacles and saucer eyes who locked his heart in a chest on a desert island after his one true love betrayed him. ![]() 6/5/2023 0 Comments Open in tubecast![]() ![]() Her first subscriber unsubscribed in protest when she first voiced feminist opinions. ![]() Her first video titled "I think therefore I am" about René Descartes was uploaded in May 2013. Thorn originally planned to record her lectures and upload them, rather than appearing in videos, but her university would not allow this. Thorn made it her mission statement to " away a philosophy degree for free". Thorn began her YouTube channel, Philosophy Tube, as an educational channel in 2013 in response to the university tuition fees tripling in England in 2012, rendering higher education less accessible. Thorn identifies as a lesbian, as of February 2022. She has given speeches at protests in favour of transgender healthcare, and advocated for transgender liberation. On 30 January 2021, Thorn came out as a trans woman. In October 2019, Thorn discussed her sexuality in her YouTube video Queer✨, where she came out as bisexual. She then trained at East 15 Acting School, completing a Master of Arts awarded by the University of Essex in 2017 before moving to London. Thorn graduated with a Scottish Master of Arts in Philosophy in 2015, coming top of her year. Andrews, where she also participated in Mermaids and the St Andrews Revue. She later studied Philosophy and Theology at the University of St. Thorn credits her discovery of philosophy to her teacher, as well as having taken the subject as an A-level course. She attended the Royal Grammar School, where she was a member of an army cadets group. ![]() Thorn is from Newcastle upon Tyne and has two older brothers. Thorn publicly came out as a transgender woman in January 2021, with the video Coming Out As Trans – A Little Public Statement and the more theatrical Identity: A Trans Coming Out Story. The transgender-themed work is based on characters in Shakespeare's Henry IV, Part 1 becoming self-aware. In September and October 2022, The Prince-a play written by and starring Thorn-ran Off West End. The stream lasted five days, featured a number of guests, and raised over £100,000 for Samaritans. In 2019, Thorn hosted a livestream on Twitch in which she read plays from the Complete Works of Shakespeare for the mental health charity Samaritans. The channel has been positively received by critics, and has over one million subscribers. In 2018, her videos became more theatrical, beginning to incorporate dramatic studio sets, lighting, costuming and makeup. Philosophy Tube began in 2013, when Thorn sought to provide free lessons in philosophy in the wake of the 2012 increase in British tuition fees. Abigail Thorn (born 24 April 1993) is a British YouTuber, actress, and playwright, best known for producing the YouTube channel Philosophy Tube. ![]() 6/5/2023 0 Comments Gnuplot script file![]() ![]() The script will run and generate the PNG file at the specified location. Gnuplot is able to generate a graphic from a script file which allows for a sequence of commands necessary to draw a graphic to be executed in sequence. In case your current folder contains the script you may enter the following instead: gnuplot sinx.p Start Gnuplot from your Mac Terminal: gnuplot gnuplot> It prompts you with gnuplot> as shown, but I won’t show that prompt in the examples below. Open your terminal and type: gnuplot path/to/sinx.p ![]() You may customize the set output line with the path you would like the file to generate the file. In the example above you find the most common commands, however, there are several other commands to be explored such as set xlabel, set ylabel, etc. For example, consider you have a script called 'test. plot is used to plot 2-d functions and data, while splot plots 3-d surfaces and data. This task is easy to be done using the Gnuplot commands. A Gnuplot script is a simple text file (with the extension. plot and splot are the primary commands in Gnuplot. ![]() Create a script fileĬreate a file sinx.p with the following contents: # Set the output to a png file Gnuplot is a free, command-driven, interactive, function and data plotting program. Gnuplot is able to generate a graphic from a script file which allows for a sequence of commands necessary to draw a graphic to be executed in sequence instead of type in manually.įor the purpose of this example we'll create a simple script to draw a sin(x). The PostScript terminal driver in gnuplot version 4.2 loads prolog information from external files into each PostScript file output by gnuplot. ![]() |